Discovery and Impact Symposium Series

Discovery and Impact Symposium Series

Join us virtually on Wednesday, June 1, from 3:00 - 4:30 p.m.

The Discovery and Impact Symposium is a monthly series where University of Oregon and Thermo Fisher Scientific researchers will shed light on new understanding and innovations in the biosciences and their potential impact in the world. This series will increase scientific interactions between UO and Thermo Fisher, foster greater partnerships, and provide insights into technologies, materials, and techniques that could further each organizations’ mission to advance society and contribute to a healthier, cleaner, and safer world.

Our next speakers will be Keat Ghee Ong, professor at the Knight Campus, and Ryan Bomgraden, senior manager of R&D at Thermo Fisher Scientific.

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Keat Ghee Ong

Professor, Knight Campus

Wireless Implants for In-Situ Biofeedback After Tendon and Ligament Repairs

Surgical repair or reconstruction is the clinical standard to treat severe cases of tendon and ligament injures; however, repair or reconstruction failures often occur due to high force/strain and instability at the injury site. Common examples of these failures are rotator cuff re-tear, flexor tendon re-rupture, Achilles tendon re-rupture, and postoperative syndesmosis instability. Therefore, monitoring forces after tendon and ligament repair becomes critically important, not only for guiding the postoperative rehabilitation regime, but also for preventing excessive force application to the repair site that can cause it to fail. Here, we present a noninvasive sensor technology for in vivo force measurement at tendon and ligament repair sites. The technology is based on embedding battery-free sensors in standard orthopedic implants such as suture anchors or suture buttons. These stress/strain-sensitive implants are monitored with a wearable device, providing real-time, continuous measurement of tendon/ligament tension both intraoperatively and postoperatively so surgeons or physical therapists can track the repair condition and detect implant failure. The proposed implant system will also provide personalized, real-time, continuous biofeedback for providers to make informed decisions regarding return to various physical activities and guide postoperative rehabilitation.

Keat Ghee Ong received his BS, MS and PhD degrees in electrical engineering from the University of Kentucky in 1997, 1998 and 2000, respectively. He joined the department of Biomedical Engineering at Michigan Technological University, Houghton, MI in 2006. In 2019, he joined the Knight Campus at the University of Oregon as professor. His research areas include implantable sensors for regenerative medicine and sensor technologies for cell manufacturing. He is also working on wireless sensor networks, magnetoelastic materials, and measurement technique and instrument automation. Ong is a senior member of National Academy of Inventors.

 

keat ghee ong

Ryan Bomgraden

Senior Manager of R&D, Thermo Fisher Scientific

Providing COVID-19 Clarity using TMT Reagents for Precision Measurements

COVID-19 is a novel disease caused by the novel coronavirus SARS-CoV-2 responsible for a global pandemic that has affected tens of millions of people worldwide. Upon infection with the virus, people exhibit a wide variety of symptoms ranging from asymptomatic to severe organ damage and systemic inflammation which can result in death. Identifying the underlying differences between people and their response to infection is paramount to determining effective treatments and predicting disease outcomes. Proteomic profiling using Tandem Mass Tags (TMT) is one technology that enables precise measurement of protein abundances from different samples and/or conditions. This seminar will highlight recent advances in TMT reagent workflows and their use in recent applications to measure SARS-CoV-2 viral particle expression over time, changes in host cell signaling upon infection, differences in immune responses of mild versus severe cases, and identify COVID-19-related drug targets and off-targets.

As a senior manager of R&D at Thermo Fisher Scientific, Ryan leads a team of scientists in the mass spectrometry reagent group focused developing novel products and workflows for the proteomics market. Ryan received his BS from Coe College with majors in chemistry and molecular biology. He completed his PhD at Stanford University under Dr. Karlene Cimprich where he characterized ATR checkpoint kinase DNA binding and signaling in UV-sensitive patient cells. In 2005, Ryan joined Pierce Biotechnology, now part of Thermo Fisher Scientific, where he has led the development of over a 100 new products including Tandem Mass Tag reagents for relative quantitation of proteomic samples, protein digest standards for LC-MS quality control, MS-cleavable crosslinkers for protein structure analysis, heavy protein IVT kits for production of stable isotope-labeled proteins; and ActivX probes for enzyme inhibitor profiling and detection.

 

ryan bomgarden

Previous Presentations

October 20, 2021
Raghuveer Parthasarathy explores the shape and form of gut microbes, while Bhaskar Mandavilli discusses practical considerations for imaging tumor spheroid models.
September 15, 2021
Paul Dalton discusses high-resolution 3D printing technology, while Dan Cash explores practical considerations in mounting media selection to optimize fluorescence microscopy experiments.
August 18, 2021
Ramesh Jasti explains how carbon nanohoops can be used as new biological imaging tools, while Yu-Zhong Zhang discusses how fluorescent microsphere calibration standards lead to improved flow cytometry analysis.
July 21, 2021
Annie Zemper explains what lessons we can learn from mouse models of inflammatory bowel disease, while Chris Vonnegut discusses the development, exploration, and application of modern nucleic acid dyes.
June 16, 2021
Calin Plesa discusses the multiplexed characterization of protein families with DropSynth Gene Synthesis and broad mutational scanning, while John Rogers examines chemical tools and applications for functional proteomics.
May 19, 2021
Bruce Bowerman explores oocyte meiotic sindle assembly and polar body extrusion in C. elegans, while Chris Langsdorf discusses how cell-based assays can be used to functionally characterize immunotherapies.
April 21, 2021
Vickie DeRose explores new methods for detecting platinum anticancer compounds, while Dan Beecham discusses probing endosomal and lysosomal dynamics with new-generation pH-sensitive probes.
February 24, 2021
Mike Pluth explores chemical tools for investigating reactive sulfur species in biological systems, while Leticia Montoya discusses the simultaneous assessment of RNA and protein expression in single cells for in-depth characterization of cellular sub-populations.